HOW DOES EMPAGLIFLOZIN WORK TO REDUCE THE RISK OF CARDIOVASCULAR EVENTS AND MORTALITY

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Yo, let me tell you about this medication called empagliflozin and how it can help reduce the risk of cardiovascular events and mortality. 🩺💊

Empagliflozin belongs to a class of medications called SGLT2 inhibitors. These drugs work by blocking a protein called SGLT2, which is responsible for reabsorbing glucose back into the bloodstream in the kidneys. By inhibiting SGLT2, empagliflozin causes excess glucose to be excreted in the urine, leading to a decrease in blood glucose levels. 🚫🍭

But that’s not all empagliflozin does. Studies have shown that this medication can also provide cardiovascular benefits. In the EMPA-REG OUTCOME trial, which involved over 7,000 patients with type 2 diabetes and established cardiovascular disease, empagliflozin was found to significantly reduce the risk of major adverse cardiovascular events, including cardiovascular death, nonfatal myocardial infarction (heart attack), and nonfatal stroke, by 14%. 😍❤️

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So how does empagliflozin achieve these cardiovascular benefits? One theory is that by causing glucose to be excreted in the urine, empagliflozin may also reduce the amount of glucose that circulates in the bloodstream. High levels of glucose in the blood can damage blood vessels and increase the risk of cardiovascular disease. Additionally, empagliflozin has been shown to reduce blood pressure and improve markers of heart function, such as left ventricular mass and ejection fraction. 🩸❤️

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It’s important to note that empagliflozin is not a substitute for a healthy lifestyle. Patients should still engage in regular physical activity, follow a balanced diet, and take any other medications prescribed by their healthcare provider. And as with any medication, empagliflozin may not be suitable for everyone and can cause side effects. Common side effects include genital yeast infections and urinary tract infections. Rare but serious side effects include ketoacidosis and leg and foot amputations. Patients should discuss the risks and benefits of empagliflozin with their healthcare provider. 💪🏾👨🏽‍⚕️

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In conclusion, empagliflozin is a medication that can help reduce blood glucose levels and provide cardiovascular benefits. It works by blocking a protein called SGLT2, which causes excess glucose to be excreted in the urine. Empagliflozin has been shown to reduce the risk of major adverse cardiovascular events by 14% in patients with type 2 diabetes and established cardiovascular disease. However, it’s important to remember that empagliflozin is not a substitute for a healthy lifestyle and can cause side effects. Patients should discuss the risks and benefits of this medication with their healthcare provider. 💊👨🏻‍⚕️

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